Corpus Christi is a coastal city in the South Texas region of the U.S. state of Texas and the county seat and largest city of Nueces County with …Corpus Christi is a coastal city in the South Texas region of the U.S. state of Texas and the county seat and largest city of Nueces County with portions extending into Aransas, Kleberg, and San Patricio counties. It is 130 miles southeast of San Antonio and 208 miles southwest of Houston. Its political boundaries encompass Nueces Bay and Corpus Christi Bay. Its zoned boundaries include small land parcels or water inlets of three neighboring counties.