Preview the Week 5 matchup between the Jacksonville Jaguars and Indianapolis Colts with predictions, odds, over/under, spread, betting lines and more.

This year, the Jaguars put up 6.3 fewer points per game (15.0) than the Colts allow (21.3). Jacksonville racks up 285.5 yards per game, 114.3 fewer yards than the 399.8 Indianapolis allows per outing. This year, the Jaguars have three turnovers, three fewer than the Colts have takeaways (6).

Watson should be working on two straight games with two-plus passing touchdowns, and he played well last week, finishing with an 88.5 passing grade from Pro Football Focus — his highest mark in a Browns jersey. The Commanders have allowed 16 of 21 opposing quarterbacks to finish with two-plus passing touchdowns.