Now comes the hard part for Kyle Shanahan — devising a game plan without Deebo Samuel and Christian McCaffrey.

San Francisco 49ers running back Christian McCaffrey has been placed on the injured reserve, but could miss more time after, ...

Think Jordan Mason (-185) scores a touchdown in Week 3? Or do you have another player in mind who you expect to hit paydirt?

Running back Jordan Mason and the San Francisco 49ers will go up against the NFL's 30th-ranked run defense when they take on ...

San Francisco 49ers safety Talanoa Hufanga was a full participant in practice for the first time since his ACL tear in Week ...

San Francisco 49ers safety Talanoa Hufanga was a full participant in practice for the first time since tearing a ligament in ...

Allegany High graduate Mason Salvadge scored his first collegiate goal, and it was the difference in Frostburg State's 2-1 ...

Los Angeles is in danger of falling way behind after making the playoffs last year. Brock Purdy still has Brandon Aiyuk, ...

With the San Francisco 49ers facing the chance of falling down 27-7, defensive captain Fred Warner came up with a big hit at ...

San Francisco 49ers running back Jordan Mason follows his blockers to go untouched into the end zone on a 10-yard run that ...

San Francisco 49ers running back Jordan Mason bounces a run to his right and shifts into high gear on a 22-yard run.

San Francisco 49ers running back Jordan Mason takes a toss play for a bruising 22-yard run that includes multiple broken ...